Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer

Methylation pattern of different regions

Methylation pattern of different regions of the MLH1 promoter and silencing of gene expression in hereditary and sporadic colorectal cancer

✍ Mirco Menigatti; Carmela Di Gregorio; Francesca Borghi; Elisa Sala; Alessandra S 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 2 views

## Abstract Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism of gene inactivation during tumorigenesis. We examined the methylation status of two distinct regions of the __MLH1__ promoter (proximal and distal to the transcription start site) and the __MLH1_