DNA methylation and expression of major histocompatibility complex class I and class II transactivator genes in human developmental tumor cells and in T cell malignancies
β Scribed by Peter J van den Elsen; Tjadine M Holling; Nienke van der Stoep; Jeremy M Boss
- Book ID
- 117792975
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 139 KB
- Volume
- 109
- Category
- Article
- ISSN
- 1090-2341
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The expression of products encoded by the major histocompatibility complex ( M H C ) on tumor cells has recently been studied exrensively. It has been found that many malignant tumor cells have their MHC antigens 'switched-off but that these antigens are re-expressed following DNA-mediated gene tran