✦ LIBER ✦

Re-expression of major histocompatibility complex (UMHC) class I molecules on malignant tumor cells and its effect on host-tumor interaction

✍ Scribed by Kam M. Hui

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 606 KB
Volume: 11
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950110107

No coin nor oath required. For personal study only.

✦ Synopsis

The expression of products encoded by the major histocompatibility complex ( M H C ) on tumor cells has recently been studied exrensively. It has been found that many malignant tumor cells have their MHC antigens 'switched-off but that these antigens are re-expressed following DNA-mediated gene transfer, with increased tumor immunogenicity as a result and the consequence that these ' transformed' tumor cells are rejected in vivo. This reaiew will discuss approaches that have been taken to induce strong tumor-specific immunity by the manipulation of MHC expression on tumor cells.

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