DNA hypomethylation and imbalanced expression of DNA methyltransferases (DNMT1, 3A, and 3B) in human uterine leiomyoma
โ Scribed by Shuanfang Li; Tung-chin Chiang; Gloria Richard-Davis; J.Carl Barrett; John A Mclachlan
- Book ID
- 114101466
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 302 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0090-8258
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DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have shown that methylation patterns become abnormal in malignant cells and may contribute to tumorigenesis by improper de novo methylation and silencing of the promoters for