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DNA cross-linking studies on FR900482 : observations on the mode of activation

โœ Scribed by Robert M. Williams; Scott R. Rajski

Book ID
104216053
Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
462 KB
Volume
33
Category
Article
ISSN
0040-4039

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โœ Manuel M. Paz; Paul B. Hopkins ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 315 KB

The antitumor antibiotics FR66979 and FR900482 are believed to undergo bioreductive activation in vivo, enabling them to alkylate DNA. Reduction has previously been accomplished in vitro using sodium dithionite or dithiothreitol. We find that metal ions are a previously unrecognized, critical compon