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Biophysical Studies on the Stability of DNA Intrastrand Cross-Links of Transplatin

✍ Scribed by Kasparkova, Jana; Marini, Victoria; Bursova, Vendula; Brabec, Viktor


Book ID
119922111
Publisher
Biophysical Society
Year
2008
Tongue
English
Weight
575 KB
Volume
95
Category
Article
ISSN
0006-3495

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The antitumor drug cisplatin low occurrence of interstrand cross-links in cisplatinated DNA is due to an extremely slow initial platination of guanines involved in d(GC) 2 sequences, rather than to a slow cross-linking reaction.