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Fast Interstrand Cross-linking of Cisplatin–DNA Monoadducts Compared with Intrastrand Chelation: A Kinetic Study Using Hairpin-Stabilized Duplex Oligonucleotides

✍ Scribed by Véronique Monjardet-Bas; Jean-Claude Chottard; Jiří Kozelka

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 133 KB
Volume: 8
Category: Article
ISSN: 0947-6539
DOI: 10.1002/1521-3765(20020301)8:5<1144::aid-chem1144>3.0.co;2-k

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✦ Synopsis

The antitumor drug cisplatin low occurrence of interstrand cross-links in cisplatinated DNA is due to an extremely slow initial platination of guanines involved in d(GC) 2 sequences, rather than to a slow cross-linking reaction.