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DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

✍ Scribed by Erickson, Leonard C.; Laurent, Guy; Sharkey, Nancy A.; Kohn, Kurt W.

Book ID: 109721579
Publisher: Nature Publishing Group
Year: 1980
Tongue: English
Weight: 360 KB
Volume: 288
Category: Article
ISSN: 0028-0836
DOI: 10.1038/288727a0

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Together with tolerance to killing induced by methylating agents, loss of mismatch repair (MMR) has previously been found to be associated with hypersensitivity to the DNAcross-linking agent 1-(2-chloroethyl)-3-cyclohexyl-nitrosourea(CCNU) in several human tumor cell lines (Aquilina et al., 1998). H