DNA-protein cross-linking between thymine and tyrosine in chromatin of γ-irradiated or H2O2-treated cultured human cells

Treatment of wistar rats with a renal ca

Treatment of wistar rats with a renal carcinogen, ferric nitrilotriacetate, causes dna-protein cross-linking between thymine and tyrosine in their renal chromatin

✍ Shinya Toyokuni; Toshiaki Mori; Hiroshi Hiai; Miral Dizdaroglu 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 673 KB

Ferric nitrilotriacetate (Fe-NTA) induces renal proximal tubular damage associated with lipid peroxidation and oxidative DNA base modifications that finally leads to a high incidence of renal adenocarcinoma in rodents. In the present study, we report on the in vivo formation of DNA-protein cross-lin