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DNA binding induces conformational transition within human DNA topoisomerase I in solution

✍ Scribed by Vladimir Oleinikov; Alyona Sukhanova; Konstantin Mochalov; Olga Ustinova; Irina Kudelina; Igor Bronstein; Igor Nabiev


Book ID
101717587
Publisher
Wiley (John Wiley & Sons)
Year
2002
Tongue
English
Weight
108 KB
Volume
67
Category
Article
ISSN
0006-3525

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DNA STRAND-BREAKS INDUCED BY THE TOPOISO
✍ P. Daza; J. Torreblanca; G. Garcı́a-Herdugo; F.J. Moreno 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 358 KB

## Abstract Camptothecin (CPT) and actinomicyn‐induced strand‐breaks, repair and apoptosis in unstimulated human blood cells were studied using the DNA comet assay, and electrophoresis of low molecular weight DNA extracts. On the one hand, incubation of G0 leukocytes for 1h with CPT induced DNA str