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Enhanced DNA topoisomerase I inhibitor-induced apoptosis by UDCA in human colon adenocarcinoma cells

✍ Scribed by Ikegami, Tadashi; Cotruvo, Joe; Ceryak, Susan; Matuszaki, Yasushi; Bouscarel, Bernard

Book ID
124134446
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
192 KB
Volume
120
Category
Article
ISSN
0016-5085

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✍ P. Daza; J. Torreblanca; G. Garcı́a-Herdugo; F.J. Moreno πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 English βš– 358 KB

## Abstract Camptothecin (CPT) and actinomicyn‐induced strand‐breaks, repair and apoptosis in unstimulated human blood cells were studied using the DNA comet assay, and electrophoresis of low molecular weight DNA extracts. On the one hand, incubation of G0 leukocytes for 1h with CPT induced DNA str