Apoptosis and Its Modulation in Human Promyelocytic HL-60 Cells Treated with DNA Topoisomerase I and II Inhibitors
β Scribed by R. Bertrand; E. Solary; J. Jenkins; Y. Pommier
- Book ID
- 115601524
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 788 KB
- Volume
- 207
- Category
- Article
- ISSN
- 0014-4827
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Topoisomerase II (TopoII) is a Mg-dependent enzyme involved in topological modifications of DNA that are crucial to the regulation of cell proliferation and possibly differentiation. To investigate the role of Mg availability in the modulation of TopoII in whole cells, we studied enzyme activity and
## Abstract We have tested the effect of several bile acids on the proliferation and differentiation of the HL60 human promyelocytic leukemia cell line __in vitro__. Deoxycholate, chenodeoxycholate and lithocholic acid caused doseβdependent inhibition of cell proliferation and induction of differen