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The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells

โœ Scribed by Giacinta Del Bino; Janusz S. Skierski; Zbigniew Darzynkiewicz


Book ID
115892604
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
727 KB
Volume
195
Category
Article
ISSN
0014-4827

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Topoisomerase II (TopoII) is a Mg-dependent enzyme involved in topological modifications of DNA that are crucial to the regulation of cell proliferation and possibly differentiation. To investigate the role of Mg availability in the modulation of TopoII in whole cells, we studied enzyme activity and