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DNA-Binding Cytotoxic Alkaloids: Comparative Study of the Energetics of Binding of Berberine, Palmatine, and Coralyne

✍ Scribed by Bhadra, Kakali; Maiti, Motilal; Kumar, Gopinatha Suresh


Book ID
120501924
Publisher
Mary Ann Liebert
Year
2008
Tongue
English
Weight
433 KB
Volume
27
Category
Article
ISSN
1044-5498

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Binding of DNA-binding alkaloids berberi
✍ Md. Maidul Islam; Prateek Pandya; Sebanti Roy Chowdhury; Surat Kumar; Gopinatha πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 English βš– 870 KB

The interaction of two natural protoberberine plant alkaloids berberine and palmatine with tRNA phe was studied using various biophysical techniques and molecular modeling and the data were compared with the binding of the classical DNA intercalator, ethidium. Circular dichroic studies revealed that