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DNA binding and selective gene induction by different forms of the p53 protein

✍ Scribed by Mayelzadeh, F; Martinez, J D


Book ID
110072114
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
205 KB
Volume
26
Category
Article
ISSN
0950-9232

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The transcription factor p53 controls the proliferation and survival of cells exposed to DNA damage. The specific DNA-binding domain of p53 (residues 102-292) has a complex tertiary structure that is stabilized by zinc. In this study, we showed that exposure of cultured cells to the membrane-permeab