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DNA Adduction by the Potent Carcinogen Aflatoxin B1: Mechanistic Studies

✍ Scribed by Iyer, Rajkumar S.; Coles, Brian F.; Raney, Kevin D.; Thier, Ricarda; Guengerich, F. Peter; Harris, Thomas M.

Book ID
126961659
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
753 KB
Volume
116
Category
Article
ISSN
0002-7863

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NMR-studies of carcinogen reactions with
NMR-studies of carcinogen reactions with DNA: Ethylene dibromide and aflatoxin B1
✍ Thomas M. Harris πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science 🌐 English βš– 849 KB

Two examples are described of the use of NMR spectroscopy to study the modification of DNA structure by carcinogens. The reaction of ethylene dibromide involves initial conjugation with glutathione, catalysed by glutathione S-transferase. Reaction of this adduct with DNA occurs at N7 of guanine. Thr