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DL-Myo-inositol 1,4,5-trisphosphorothioate mobilizes intracellular calcium in Swiss 3T3 cells and Xenopus oocytes

✍ Scribed by Colin W Taylor; Michael J Berridge; Kenneth D Brown; Allan M Cooke; Barry V.L. Potter


Book ID
115761174
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
432 KB
Volume
150
Category
Article
ISSN
0006-291X

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The functional significance of the 2- and 3-hydroxyl groups of 1 D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] was probed by using Ins(1,4,5)P3 analogues variously modified at positions 2 and 3 or elsewhere. The intrinsic activities of these compounds were compared to that of Ins(1,4,5)P3, using