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The role of the 2- and 3-hydroxyl groups of 1d-myo-inositol 1,4,5-trisphosphate in the mobilisation of calcium from permeabilised human 1321N1 astrocytoma cells

✍ Scribed by Robert A. Wilcox; Stefan R. Nahorski; Deborah A. Sawyer; Changsheng Liu; Barry V.L. Potter

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 707 KB
Volume: 234
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(92)85051-z

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✦ Synopsis

The functional significance of the 2- and 3-hydroxyl groups of 1 D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] was probed by using Ins(1,4,5)P3 analogues variously modified at positions 2 and 3 or elsewhere. The intrinsic activities of these compounds were compared to that of Ins(1,4,5)P3, using the calcium-mobilising receptor of the 1321N1 human astrocytoma cell line. The ligand-binding affinities were also determined using membrane preparations from rat cerebellum and bovine adrenal cortex. The results show that HO-2 and HO-3 of Ins(1,4,5)P3 have a relatively insignificant role in receptor binding and calcium release. However, the possibility of a regulatory role for the 3-position of Ins(1,4,5)P3 in these processes is proposed.

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