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Synthesis of the first optically pure, fluorinated inositol 1,4,5-trisphosphate of myo-inositol. Stereochemistry and its effect on calcium(2+) release in Swiss 3T3 cells

โœ Scribed by Kozikowski, Alan P.; Fauq, Abdul H.; Aksoy, Ibrahim A.; Seewald, Markus J.; Powis, Garth


Book ID
127087922
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
301 KB
Volume
112
Category
Article
ISSN
0002-7863

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The role of the 2- and 3-hydroxyl groups
โœ Robert A. Wilcox; Stefan R. Nahorski; Deborah A. Sawyer; Changsheng Liu; Barry V ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 707 KB

The functional significance of the 2- and 3-hydroxyl groups of 1 D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] was probed by using Ins(1,4,5)P3 analogues variously modified at positions 2 and 3 or elsewhere. The intrinsic activities of these compounds were compared to that of Ins(1,4,5)P3, using