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Diversity Synthesis of Pyrimido[4,5- b ][1,6]naphthyridine and Its Derivatives under Microwave Irradiation

✍ Scribed by Han, Zheng-Guo; Zhang, Ge; Jiang, Bo; Ma, Ning; Shi, Feng; Tu, Shu-Jiang

Book ID: 126486892
Publisher: American Chemical Society
Year: 2009
Tongue: English
Weight: 245 KB
Volume: 11
Category: Article
ISSN: 1520-4766
DOI: 10.1021/cc800196u

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## Abstract Ethyl 1‐ethyl‐7‐methyl‐4‐oxo‐1,4‐dihydro[1,8]naphthyridine‐3‐carboxylate (**1**), precursor of nalidixic acid, has been converted in two steps through ([1,8]naphthyridin‐3‐yl)carbonylguanidine derivatives into substituted pyrimido[4,5‐__b__] and [5,4‐__c__][1,8]naphthyridines.