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Diversity and Complexity of Ceramide Signalling in Apoptosis

✍ Scribed by Toshiro Okazaki; Tadakazu Kondo; Toshiyuki Kitano; Masaro Tashima

Book ID: 114284165
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 244 KB
Volume: 10
Category: Article
ISSN: 0898-6568
DOI: 10.1016/s0898-6568(98)00035-7

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A novel pathway termed the sphingomyelin cycle has been identified whereby membrane sphingomyelin is hydrolyzed in response to multiple extracellular stimuli (such as tumor necrosis factor a ) which cause activation of regulated sphingomyelinases. The product, ceramide, has emerged as a second messe