𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Ceramide: A stress signal and mediator of growth suppression and apoptosis

✍ Scribed by Lina M. Obeid; Yusuf A. Hannun

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
787 KB
Volume
58
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

A novel pathway termed the sphingomyelin cycle has been identified whereby membrane sphingomyelin is hydrolyzed in response to multiple extracellular stimuli (such as tumor necrosis factor a ) which cause activation of regulated sphingomyelinases. The product, ceramide, has emerged as a second messenger that mediates many of the cellular effects of these extracellular stimuli. An intriguing relation exists between activation of the sphingomyelin cycle and the action of multiple stress stimuli that induce growth arrest and programmed cell death. Exogenously administered ceramide mimics these growth-suppressing effects, including the induction of apoptosis. This review will highlight the role of the sphingomyelin cycle in signal transduction and will focus on the role and function of ceramide in the regulation of cell growth in general and apoptosis specifically.

📜 SIMILAR VOLUMES

Nerve growth factor signaling of p75 ind
Nerve growth factor signaling of p75 induces differentiation and ceramide-mediated apoptosis in Schwann cells cultured from degenerating nerves
✍ Hitoshi Hirata; Hiroshige Hibasami; Toshimichi Yoshida; Masaru Ogawa; Mamoru Mat 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 829 KB

## Abstract In peripheral nerve regeneration or remyelination, immature Schwann cells expressing p75^NTR^ play cardinal roles in the support and regeneration of axons (Griffin JW, Hoffman PN. Peripheral Neuropathy 361–376, 1993). Only one of four to six Schwann cells participate in remyelination of

Ferritin—a mediator of apoptosis?
Ferritin—a mediator of apoptosis?
✍ Nikolaus Bresgen; Ingo Ohlenschläger; Brigitte Fiedler; Nathalie Wacht; Susanne 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 294 KB

## Abstract Previously we have demonstrated an apoptosis inducing activity for a rat hepatocyte conditioned medium (CM) presumably mediated by acidic isoferritins. Here, we present support for this assumption since isoferritins purified from different rat hepatocyte CM significantly enhanced the fr

Synthesis of 7-Oxasphingosine and -ceram
Synthesis of 7-Oxasphingosine and -ceramide Analogues and Their Evaluation in a Model for Apoptosis
✍ Roshini Rajan; Kurt Wallimann; Andrea Vasella; Deborah Pace; Armando A. Genazzan 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 333 KB 👁 2 views

## Abstract The 7‐oxasphingosine (**1**), 7‐oxaceramide (**2**), the thio‐oxaceramide **3**, and __N__‐methyloxaceramide **4** were synthesised from D‐galactose __via__ the building block **9**. The apoptosis‐inducing properties of **1**–**4** were compared to those of sphingosine (Sph) and ceramid