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Stress signals for apoptosis: ceramide and c-Jun kinase

✍ Scribed by Basu, Subham; Kolesnick, Richard

Book ID
110062009
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
640 KB
Volume
17
Category
Article
ISSN
0950-9232

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A novel pathway termed the sphingomyelin cycle has been identified whereby membrane sphingomyelin is hydrolyzed in response to multiple extracellular stimuli (such as tumor necrosis factor a ) which cause activation of regulated sphingomyelinases. The product, ceramide, has emerged as a second messe