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Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells

✍ Scribed by Sen, Alaattin; Ozgun, Ozden; Arinç, Emel; Arslan, Sevki


Book ID
113063190
Publisher
Springer
Year
2012
Tongue
English
Weight
588 KB
Volume
28
Category
Article
ISSN
0742-2091

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a