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Differential expression of glutathione S-transferases P1-1 and A1-1 at protein and mRNA levels in hepatocytes derived from human bone marrow mesenchymal stem cells

✍ Scribed by Abdolamir Allameh; Shahnaz Esmaeli; Somaieh Kazemnejad; Masoud Soleimani


Book ID
116919981
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
412 KB
Volume
23
Category
Article
ISSN
0887-2333

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a