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The influence of cytochrome P450 1A1 and glutathione S-transferase M1 genotypes on biomarker levels in coke-oven workers

✍ Scribed by G. Brescia; L. Celotti; E. Clonfero; H. G. Neumann; A. Forni; V. Foà; M. Pisoni; G. M. Ferri; G. Assennato


Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
594 KB
Volume
73
Category
Article
ISSN
0340-5761

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a