The impact of glutathione s-transferase
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Nathaniel Rothman; Peter G. Shields; Miriam C. Poirier; Anita M. Harrington; D.
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Article
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1995
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John Wiley and Sons
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English
⚖ 616 KB
## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a