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Diureas as Ligands in Asymmetric Reduction of Ketones

✍ Scribed by Gamez, Patrick; Dunjic, Branko; Lemaire, Marc


Book ID
121225592
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
181 KB
Volume
61
Category
Article
ISSN
0022-3263

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Chiral thiourea as ligand for the asymme
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The catalytic enantioselective reduction of prochiral ketones using a chiral thiourea as ligand is reported. Several metallic precursors were tested. e.e.'s up to 94% are obtained with a ruthenium complex.

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1997 stereochemistry stereochemistry (general, optical resolution) O 0030 30 -032 Chiral Thiourea as Ligand for the Asymmetric Reduction of Prochiral Ketones. -Prochiral ketones are reduced enantioselectively using the chiral thiourea ligand CTU with various metal catalysts. Best yields and selectiv

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Bimorpholine and 3,3%-bimorpholine were used as chiral ligands in Rh-mediated asymmetric hydride transfer reduction of prochiral aromatic ketones affording corresponding alcohols with good ee (up to 75%).