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Disturbance of 6-mercaptopurine metabolism by cotrimoxazole in childhood lymphoblastic leukaemia

โœ Scribed by Corinne A. Rees; Lynne Lennard; John S. Lilleyman; John L. Maddocks

Book ID
104684889
Publisher
Springer
Year
1984
Tongue
English
Weight
253 KB
Volume
12
Category
Article
ISSN
0344-5704

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๐Ÿ“œ SIMILAR VOLUMES

Thiopurine methyltransferase deficiency
Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies
โœ Lennard, Lynne; Lewis, Ian J.; Michelagnoli, Maria; Lilleyman, John S. ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 76 KB

Daily 6-mercaptopurine (6MP) forms the backbone of continuing chemotherapy for childhood lymphoblastic leukaemia (ALL). A major metabolic route is catalysed by thiopurine methyltransferase (TPMT). TPMT deficiency occurs in 1 in 300 individuals and results in high concentrations of thioguanine nucleo