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Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia

โœ Scribed by J.S. Lilleyman; L. Lennard


Book ID
118556324
Publisher
The Lancet
Year
1994
Tongue
English
Weight
430 KB
Volume
343
Category
Article
ISSN
0140-6736

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Thiopurine methyltransferase deficiency
โœ Lennard, Lynne; Lewis, Ian J.; Michelagnoli, Maria; Lilleyman, John S. ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 76 KB

Daily 6-mercaptopurine (6MP) forms the backbone of continuing chemotherapy for childhood lymphoblastic leukaemia (ALL). A major metabolic route is catalysed by thiopurine methyltransferase (TPMT). TPMT deficiency occurs in 1 in 300 individuals and results in high concentrations of thioguanine nucleo