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Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

✍ Scribed by Lennard, L.; Lilleyman, J.S.; Van Loon, J.; Weinshilboum, R.M.

Book ID
122959411
Publisher
The Lancet
Year
1990
Tongue
English
Weight
642 KB
Volume
336
Category
Article
ISSN
0140-6736

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Intraindividual variation in 6-mercaptop
Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia
✍ P. Lafolie; S. Hayder; O. BjΓΆrk; C. Peterson πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 318 KB

Intraindividual variation in 6-mercaptopurine (6-MP) kinetics has been little studied. It has now been examined in 18 children with acute lymphoblastic leukaemia (ALL). On 2 to 4 occasions in each patient drug concentrations in plasma and red cells were followed for 4 h after administration by means