Myelin basic protein (MBP) mRNA is localized to the myelin membranes of oligodendrocytes. When exogenous MBP mRNA is microinjected into oligodendrocytes in culture, it is transported along the processes and localized to the myelin compartment in a multistep intracellular RNA trafficking pathway. In
Distribution of Myelin Basic Protein and P2 mRNAs in Rabbit Spinal Cord Oligodendrocytes
โ Scribed by C. S. Gillespie; B. D. Trapp; D. R. Colman; P. J. Brophy
- Book ID
- 111175482
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 704 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3042
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Myelin basic protein (MBP) is one of the most important myelin components. Based on our previous shidies, we hypothesized that neurons might have regulatory effects on the production of MBP by oligodendrocytes, and we conducted studies designed to verify this hypothesis. Oligodendroglia-rich culture
## Abstract The myelin basic protein (MBP) gene produces two families of proteins, the classic MBPs, important for myelination of the CNS, and the golli proteins, whose biological role in oligodendrocytes (OLs) is still unknown. The goals of this work were to study the in vitro pattern of expressio