Distribution of insulin receptors among mouse liver endomembranes
✍ Scribed by Ellen E. Schilling; Hans Goldenberg; D.James Morré; Frederick L. Crane
- Book ID
- 115724398
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 840 KB
- Volume
- 555
- Category
- Article
- ISSN
- 0005-2736
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Acute hyperinsulinaemias induced by insulin and stimulants of insulin secretion have been shown to cause a translocation of liver insulin receptors from the cell surface to the intracellular compartment, with little or no change in total receptor number. To determine whether a similar phenomenon occ
Insulin receptors from H-2k mouse liver membranes were specifically labelled using a photoreactive insulin analogue coupled to the alpha-subunit (Mr 130,000) of the receptor by ultraviolet-irradiation. Up to 25% of the labelled insulin receptors recovered after membrane solubilization and precipitab