Frog brain and liver show evolutionary conservation of tissue-specific differences among insulin receptors

Insulin receptors in lizard brain and li

Insulin receptors in lizard brain and liver: structural and functional studies ofαandβsubunits demonstrate evolutionary conservation

✍ J. Shemer; J. C. Penhos; Derek LeRoith 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 1003 KB

Specific insulin receptors are present in the liver and brain of the lizard Anolis carolinesis. In this study, the specific binding of 12sI-insulin to the receptors showed time, temperature and pH dependency. Specific binding to crude membranes prepared from brain was 1-2% of the total radioactivity