Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients
✍ Scribed by Marco Catalano; Maria Nobile; Emanuela Novelli; Markus M. Nöthen; Enrico Smeraldi
- Book ID
- 118856407
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 641 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0006-3223
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The dopamine D4 receptor gene (DRD4) and its products are of great interest in many neuropsychiatric disorders. There are at least five expressed polymorphisms in exons 1 and 3, plus rare expressed variants, all of which may have functional relevance. Several studies have described methods for study
The dopamine D4 receptor (DRD4) gene exhibits a large amount of expressed polymorphism in humans. To understand the evolutionary history of the first exon of DRD4which in humans contains a polymorphic 12bp tandem duplication, a polymorphic 13bp deletion, and other rare variants-we examined the homol