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Rapid molecular haplotyping of the first exon of the human dopamine D4 receptor gene by heteroduplex analysis

✍ Scribed by Chang, Fong-Ming; Kidd, Kenneth K.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 113 KB
Volume: 74
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19970221)74:1<91::aid-ajmg18>3.0.co;2-m

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✦ Synopsis

The dopamine D4 receptor gene (DRD4) and its products are of great interest in many neuropsychiatric disorders. There are at least five expressed polymorphisms in exons 1 and 3, plus rare expressed variants, all of which may have functional relevance. Several studies have described methods for studying the exon 3 polymorphisms, especially the VNTR; fewer reports have documented the exon 1 polymorphisms and variants of DRD4. We report here a simple, rapid, nonisotopic, nondenaturing heteroduplex method for determining the molecular haplotype composed of the two more polymorphic systems of the first exon of DRD4: the 12 bp duplication and 13 bp deletion. This method will facilitate future research on expressed variation of this gene.

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