Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability
β Scribed by J.R. Jass; M.D. Walsh; M. Barker; L.A. Simms; J. Young; B.A. Leggett
- Book ID
- 117658893
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 490 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0959-8049
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The reproducibility of microsatellite instability from different regions of the same sporadic colon cancer has not been addressed. We therefore microdissected and extracted DNA from three to nine separate regions of 13 highly unstable sporadic colon cancers. Each region was then evaluated by polymer
## Abstract Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are wellβcharacterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup i