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Distinct effects of atypical 1,4-dihydropyridines on 1-methyl-4-phenylpyridinium-induced toxicity

✍ Scribed by Linda Klimaviciusa; Vija Klusa; Gunars Duburs; Allen Kaasik; Anti Kalda; Alexander Zharkovsky


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
114 KB
Volume
25
Category
Article
ISSN
0263-6484

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Species difference in the susceptibility to l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) was investigated in cultured rat and mouse astrocytes, where 1-methyl-4-phenylpyridinium (MPP+), the toxic mediator of MPTP, is formed. Type A monoamine oxidase (MAO) predominated in both rat and mouse as