𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Metabolic effects of 1-methyl-4-phenylpyridinium (MPP+) in primary neuron cultures

✍ Scribed by Ann M. Marini; Thaddeus S. Nowak Jr.


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
115 KB
Volume
62
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Production and disposition of 1-methyl-4
✍ Dr. Donato A. Di Monte; Ellen Y. Wu; Ian Irwin; Louis E. Delanney; J. William La πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 805 KB

Dopaminergic neurons are a primary target for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. However, the conversion of MPTP to its neurotoxic 1-methyl-4-phenylpyridinium metabolite (MPP+ ) is likely to occur in astrocytes via the monoamine oxidase (MA0)-dependent formation of th

Differences in the disposition and toxic
✍ May J. Tsai; Dr. Eminy H. Y. Lee πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 735 KB

Species difference in the susceptibility to l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) was investigated in cultured rat and mouse astrocytes, where 1-methyl-4-phenylpyridinium (MPP+), the toxic mediator of MPTP, is formed. Type A monoamine oxidase (MAO) predominated in both rat and mouse as

In VivoHydroxylation of the Neurotoxin,
✍ Boismenu, Daniel; Mamer, Orval; Ste-Marie, Line; Vachon, Luc; Montgomery, Jane πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 849 KB

The neurotoxin 1-methyl-4-phenylpyridinium ( I MP€ ' +) has been shown to increase hydroxyl radical formation in the striatum. The production of hydroxyl radicals correlates with the MPP+-driven dopamine release which presumably leads to increased metabolism via monoamine oxidase or increased dopami

Effects of the conformationally restrict
✍ Carmen Vale; M. Teresa VilarΓ³; Eduardo RodrΓ­guez-FarrΓ©; Cristina SuΓ±ol πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 217 KB πŸ‘ 2 views

The effects of the GABA analogues, cis-and trans-4aminocrotonic acid (ACA) on GABA A receptor function and GABA uptake, together with the presence of -1 subunit mRNA and putative GABA C receptors, were studied in primary cultures of neocortical neurons and cerebellar granule cells. Both isomers indu