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Distal control of the pig whey acidic protein (WAP) locus in transgenic mice

✍ Scribed by Soraya Saidi; Sylvie Rival-Gervier; Nathalie Daniel-Carlier; Dominique Thépot; Caroline Morgenthaler; Céline Viglietta; Sonia Prince; Bruno Passet; Louis-Marie Houdebine; Geneviève Jolivet

Book ID
116507897
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
553 KB
Volume
401
Category
Article
ISSN
0378-1119

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## Abstract Whey acidic protein (WAP) is a major whey protein secreted in rodents' milk. Murine WAP (mWAP) genes have been assumed to be expressed solely in the mammary gland. However, several heterologous genes fused with the mWAP promoter and artificially introduced into animal genomes as transge

Rabbit whey acidic protein gene upstream
Rabbit whey acidic protein gene upstream region controls high-level expression of bovine growth hormone in the mammary gland of transgenic mice
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## Abstract Transgenic mice were produced which secreted high levels of bGH into milk. The 6.3‐kb upstream region of the rabbit whey acidic protein (rWAP) gene was linked to the structural part of the bovine growth hormone (bGH) gene, and the chimeric gene was introduced into mouse oocytes. bGH was