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Regulated expression of the mouse whey acidic protein gene in transgenic swine

✍ Scribed by V.G. Pursel; R.J. Wall; L. Hennighausen; C.W. Pittius; D. King


Book ID
118378795
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
63 KB
Volume
33
Category
Article
ISSN
0093-691X

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## Abstract Transgenic mice were produced which secreted high levels of bGH into milk. The 6.3‐kb upstream region of the rabbit whey acidic protein (rWAP) gene was linked to the structural part of the bovine growth hormone (bGH) gene, and the chimeric gene was introduced into mouse oocytes. bGH was

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## Abstract Whey acidic protein (WAP) is a major whey protein secreted in rodents' milk. Murine WAP (mWAP) genes have been assumed to be expressed solely in the mammary gland. However, several heterologous genes fused with the mWAP promoter and artificially introduced into animal genomes as transge