Regulated expression of the mouse whey acidic protein gene in transgenic swine
β Scribed by V.G. Pursel; R.J. Wall; L. Hennighausen; C.W. Pittius; D. King
- Book ID
- 118378795
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 63 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0093-691X
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## Abstract Transgenic mice were produced which secreted high levels of bGH into milk. The 6.3βkb upstream region of the rabbit whey acidic protein (rWAP) gene was linked to the structural part of the bovine growth hormone (bGH) gene, and the chimeric gene was introduced into mouse oocytes. bGH was
## Abstract Whey acidic protein (WAP) is a major whey protein secreted in rodents' milk. Murine WAP (mWAP) genes have been assumed to be expressed solely in the mammary gland. However, several heterologous genes fused with the mWAP promoter and artificially introduced into animal genomes as transge