Dissolution rate of p-aminobenzoates from solid xylitol dispersions

✍ Scribed by Ilari Sirenius; Veli E. Krogerus; Tuula Leppänen

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 253 KB
• Volume: 68
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600680633

✦ Synopsis

Xylitol was studied as a carrier in solid dispersions because of its low melting point and stability up to 180 degrees. It is more stable than sucrose and does not enter into Maillard reactions. Solid dispersions were prepared from esters of p-aminobenzoic acid and xylitol by the melting method and were compressed into tablets. The p-aminobenzoate dissolution rates were determined by a modified beaker method. The increase in the dissolution rates was greatest at the lowest drug levels. When the dispersion drug content exceeded 20-30%, the dissolution rate per unit area remained nearly constant. In the latter case, the increase in the dissolution rate was primarily due to an increase in area. When the carbon chain length was increased in the homologous series, the dissolution rate from the xylitol dispersions showed a nearly linear decrease.