Nimodipine (NM) solid dispersions (SD) were prepared by hot-melt extrusion with polyvinylpyrrolidone/vinyl acetate copolymer (PVP-VA; Kollidon VA64) as the carrier, then the extrudate was stored at different temperatures (20Β°C, 40Β°C, 60Β°C) after milling. Conventional differential scanning calorimetr
Crystallinity and dissolution rate of tolbutamide solid dispersions prepared by the melt method
β Scribed by James W. McGinity; Philippe Maincent; Hugo Steinfink
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 480 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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The dissolution rate of a homologous series of parabens and their dispersions in PEG 4βΓβ10(3) was examined. In light of these measurements, the release behavior of the substances from extended release hydrophilic matrix tablets based on PEO 5βΓβ10(6) was studied. Tablet release was examined for mat
Poorly soluble crystals of tolbutamide were modified in the presence of a soluble polymer or surfactant by the spherical crystallization technique, the objective being to improve the dissolution rate and to transform platelet crystals into spherical agglomerates. An HCI solution was added to a tolbu