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Improving the dissolution and oral bioavailability of the poorly water-soluble drug aloe-emodin by solid dispersion with polyethylene glycol 6000

✍ Scribed by Hao-gang Duan; Yu-hui Wei; Bo-xia Li; Hong-yan Qin; Xin-an Wu


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
214 KB
Volume
70
Category
Article
ISSN
0272-4391

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Several formulation approaches were attempted to improve the dissolution and the oral absorption of ER-34122, which is a novel dual 5-lipoxygenase/ cyclooxygenase inhibitor with potent anti-inΒ―ammatory activity. The solid dispersion of ER-34122 with hydroxypropylmethylcellulose (TC-5RW), which is an