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Enhancement of dissolution rate of rofecoxib using solid dispersions with urea

✍ Scribed by Chengsheng Liu; Kashappa Goud H. Desai; Chenguang Liu; Hyun J. Park


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
188 KB
Volume
63
Category
Article
ISSN
0272-4391

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Dissolution rate of p-aminobenzoates fro
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Xylitol was studied as a carrier in solid dispersions because of its low melting point and stability up to 180 degrees. It is more stable than sucrose and does not enter into Maillard reactions. Solid dispersions were prepared from esters of p-aminobenzoic acid and xylitol by the melting method and