The dissolution rates of each component in compressed spheres consisting of three components were measured under sink conditions. A film diffusion model is discussed and presented diagrammatically to illustrate the 13 possible dissolution behaviors of a three-component solid. Experimental dissolutio
โฆ LIBER โฆ
Dissolution kinetics of a three-component solid II: Benzoic acid, salicylic acid, and salicylamide
โ Scribed by E. L. Parrott; M. Simpson; D. R. Flanagan
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 354 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3549
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The major route of biotransformation of benzoic acid and salicylic acid in man is conjugation with glycine, resulting in the formation of hippuric acid and salicyluric acid, respectively. Both processes are capacity-limited in the usual dose range and approach a maximum rate following administration