Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical acids and their sodium salts II: Salicylic acid, theophylline, and benzoic acid

Effect of diffusion layer pH and solubil

Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical bases and their hydrochloride salts I: Phenazopyridine

✍ Abu T. M. Serajuddin; Charles I. Jarowski 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 672 KB

The pH-solubility profile of phenazopyridine as determined by the addition of HCl or NaOH solutions to its aqueous suspension was identical to that of its hydrochloride salt except during phase transition from base to salt. With the addition of HCl to a suspension of the base, the pH dropped to a ce