Six children with grade I1 astrocytomas were treated with combination chemotherapy consisting of 1,3 bis(2-chloroethyl) 1-nitrosourea (BCNU), Vincristine (VCR), intrathecal Methotrexate ( i t . MTX), and Dexamethasone. Of the children, 3 showed a partial remission, and 1 other showed clinical improv
Dissemination of low grade intracranial astrocytomas in children
β Scribed by Ian F. Pollack; Mark Hurtt; Dachling Pang; A. Leland Albright
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 961 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Background Cytogenetic analysis in certain tumors is a vital part of classification and assignment of prognosis. Few studies have examined the value of cytogenetic analysis in pediatric brain tumors. This is especially true of lowβgrade astrocytomas (LGA) of childhood. This study ex
## Background: In incompletely resected low-grade supratentorial astrocytoma, long-term survival is poor; the effect of any additional treatment to surgery still remains poorly defined. the aim of this study was to evaluate the response, the survival, and the benefit of concomitant chemoradiotherap
Thirty-eight WHO grade II astrocytomas and I0 malignant recurrent gliomas in these patients were examined for the presence of TP.53 alterations. Seventeed38 low grade astrocytomas and 6/10 malignant recurrent tumors harbored mutations of the gene detected by SSCP analysis and direct sequencing of PC
## Abstract Lowβgrade astrocytomas (LGAs) are the most common type of brain tumor in children. Until recently, very little was known about the underlying biology and molecular genetics of these tumors. However, within the past year a number of studies have shown that the MAPK pathway is constitutiv