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Chemotherapy in recurrent noncystic low-grade astrocytomas of the cerebrum in children

✍ Scribed by Timur Sumer; Dr. Arnold I. Freeman; Michael Cohen; Alfonso M. Bremer; P. R. M. Thomas; Lucius F. Sinks

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 603 KB
Volume: 10
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930100108

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✦ Synopsis

Six children with grade I1 astrocytomas were treated with combination chemotherapy consisting of 1,3 bis(2-chloroethyl) 1-nitrosourea (BCNU), Vincristine (VCR), intrathecal Methotrexate ( i t . MTX), and Dexamethasone. Of the children, 3 showed a partial remission, and 1 other showed clinical improvement. Our data suggest that chemotherapy is effective in low-grade astrocytomas, and there is now a need for larger trials in low-grade astrocytomas to document the role of chemotherapy accurately in these tumors. It is suggested that trials of chemotherapy as adjuvant to surgery and radiotherapy should be initiated.

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