✦ LIBER ✦

MAPK pathway activation and the origins of pediatric low-grade astrocytomas

✍ Scribed by Ruth G. Tatevossian; Andrew R.J. Lawson; Tim Forshew; Guy F.L. Hindley; David W. Ellison; Denise Sheer

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 273 KB
Volume: 222
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21978

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Low‐grade astrocytomas (LGAs) are the most common type of brain tumor in children. Until recently, very little was known about the underlying biology and molecular genetics of these tumors. However, within the past year a number of studies have shown that the MAPK pathway is constitutively activated in a high proportion of LGAs. Several genetic aberrations which generate this deregulation of the MAPK pathway have been identified, most notably gene fusions between KIAA1549 and BRAF. In this review we summarize these findings, discuss how these gene fusions may arise and consider possible implications for diagnosis and treatment. J. Cell. Physiol. 222: 509–514, 2010. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Chemotherapy in recurrent noncystic low-

Chemotherapy in recurrent noncystic low-grade astrocytomas of the cerebrum in children

✍ Timur Sumer; Dr. Arnold I. Freeman; Michael Cohen; Alfonso M. Bremer; P. R. M. T 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 603 KB

Six children with grade I1 astrocytomas were treated with combination chemotherapy consisting of 1,3 bis(2-chloroethyl) 1-nitrosourea (BCNU), Vincristine (VCR), intrathecal Methotrexate ( i t . MTX), and Dexamethasone. Of the children, 3 showed a partial remission, and 1 other showed clinical improv

Skeletal muscle cell activation by low-e

Skeletal muscle cell activation by low-energy laser irradiation: A role for the MAPK/ERK pathway

✍ Gavriela Shefer; Uri Oron; Andrey Irintchev; Anton Wernig; Orna Halevy 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB

TGF-β2 stimulates cranial suture closure

TGF-β2 stimulates cranial suture closure through activation of the Erk-MAPK pathway

✍ Sang-Won Lee; Kang-Young Choi; Je-Yoel Cho; Sung-Hwa Jung; Kun-Bae Song; Eui-Kyu 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB

## Abstract Cranial sutures are important growth sites of the skull. During suture closure, the dura mater is one of the most important sources of various positive and negative regulatory signals. Previous results indicate that TGF‐β2 from dura mater strongly accelerates suture closure, however, it

CCR8-dependent activation of the RAS/MAP

CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/CCL1 and vMIP-I

✍ Jamila Louahed; Sofie Struyf; Jean-Baptiste Demoulin; Marc Parmentier; Jacques V 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB

## Abstract We have previously shown that the CC‐chemokine I‐309 (CCL1) protects mouse thymic lymphomas against corticoid‐induced apoptosis. Here, we analyzed the signal transduction pathways involved in this activity on BW5147 lymphoma. Inhibition of the CCL1 activity by pertussis toxin suggested

Characterization of the signal transduct

Characterization of the signal transduction pathways mediating noradrenaline-stimulated MAPK activation and c-fos expression in oligodendrocyte progenitors

✍ Amani Khorchid; Jorge N. Larocca; Guillermina Almazan 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB 👁 2 views

In examining the signaling transduction pathway of adrenoceptors in oligodendrocyte progenitors, we have found that stimulation of ␣ 1 -adrenoceptors with norepinephrine (NE), in the presence of 3 M propranolol, increased the activity of mitogen-activated protein kinases (MAPKs). This stimulation wa

MHC class II molecules activate NFAT and

MHC class II molecules activate NFAT and the ERK group of MAPK through distinct signaling pathways in B cells

✍ Romney S. Haylett; Norbert Koch; Lothar Rink 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 342 KB 👁 1 views