Dissection of the structure and activity
Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis
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Fersht, Alan R.
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Article
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1987
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American Chemical Society
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English
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To understand an enzyme reaction, one has to characterize the bound substrates, intermediates, products, and transition states on the reaction pathway and determine the interaction energies between them and the enzyme as the reaction proceeds. Site-directed mutagenesis is invaluable in this task, en